2016年

Category-1: Hematopoiesis and Immune Environment
3-E-W30-2-O/P
Local function of the IL-15 niche in thymus
Guangwei Cui (Kyoto University)
3-E-W30-10-O/P
An organ-wide transcriptome of collagen-producing cells identifies the core signature of steady-state murine fibroblasts
Shigeyuki Shichino (The University of Tokyo, AMED)

Category-2: B cells
2-B-W16-10-O/P
Dynamics of IRF4-dependent gene activation and repression during plasma cell differentiation
Kyoko Ochiai (Tohoku University School of Medicine, AMED-CREST)
2-B-W16-14-O/P
LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-κB activation
Keiko Morimoto (Osaka University)

Category-3: T cells
1-G-W13-3-O/P
Timing and duration of MHC-I positive selection signals in the thymus reveal a novel compensatory signaling mechanism that prevents lineage fate errors
Motoko Kimura (Chiba University)
1-G-W14-11-O/P
Membrane lipid binding by SH2 domains of Lck and Zap70 regulates T cell receptor activation
You-Me Kim (Pohang University of Science and Technology)

Category-4: Helper T cells
3-G-W34-3-O/P
Gai-coupled non-canonical Hedgehog signaling in human Naive CD4 T lymphocytes.
Olga Elisseeva (Okinawa Institute of Science and Technology Graduate University)
3-G-W34-5-O/P
The microRNA-183/96/182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression
Kenji Ichiyama (Osaka University, Children's National Medical Center)

Category-5: Regulatory T cells
3-G-W35-5-O/P
Soluble form of CTLA-4 produced by regulatory T cells facilitates M2 macrophage differentiation in auto-inflammatory condition.
Motonao Osaki (Kyoto University, Osaka University)
3-G-W35-8-O/P
Immunological significance of dual secretion of TGF-β3 and IL-10 from regulatory T cells
Toshihiko Komai (The University of Tokyo)

Category-6: Innate lymphocytes
1-C-W5-3-O/P
Identification of an alternative developmental pathway of Va14+ NKT cells from double-negative thymocytes
Nyambayar Dashtsoodol (RIKEN-IMS, Mongolian National University)
1-C-W6-7-O/P
IFN regulatory factor 2 controls ILC development by promoting PLZF+ILC progenitor generation.
Yohei Okubo (Shinshu University)

Category-7: Dendritic cells and macrophages
1-B-W3-1-O/P
Single-cell RNA-seq reveals a novel dendritic cell-primed early progenitor population
Daisuke Kurotaki (Yokohama City University)
1-B-W4-4-O/P
MafB is the primary regulator of complement component C1q
Michito Hamada (University of Tsukuba)

Category-10: Mast cells & granulocytes
2-E-W19-4-O/P
A critical role of ceramide-CD300f interaction in septic peritonitis
Kumi Izawa (Juntendo University)
2-E-W19-16-P
Basophil-selective tryptase mMCP-11 plays crucial roles in the development of IgE-mediated chronic allergic inflammation in the skin.
Misako Iki (Tokyo Medical and Dental University)

Category-11: Allergy
3-D-W28-5-O/P
The role of Tfh cells and DCs in particulate-induced iBALT formation in the lungs
Etsushi Kuroda (Osaka University, Health and Nutrition)
3-D-W29-6-O/P
Clec10a suppresses Der f-induced immune response and dermatitis
Kazumasa Kanemaru (University of Tsukuba)

Category-12: Cytokines and chemokines
2-G-W21-1-O/P
Regulation of IL-4 production in Group2 innate lymphoid cells
Yasutaka Motomura (RIKEN-IMS)
2-G-W21-5-O/P
HBV-induced exosomal miRNAs down-regulate the expression of IL-21 mRNA by binding to its 3’UTR
Yutaka Enomoto (The University of Tokyo)

Category-13: Immunological memory
3-F-W33-2-O/P
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance
Shiki Takamura (Kindai University)
3-F-W33-4-O/P
Molecular mechanisms for prevention of IgE-memory formation by membrane IgE
Kei Haniuda (Tokyo University of Science)

Category-14: Virus infection
1-E-W9-3-O/P
Visualizing immune responses to influenza virus in mouse lung by using two-photon microscopy
Hiroshi Ueki (The University of Tokyo)
1-E-W10-1-O/P
Modulation of the antiviral adaptor IPS-1-mediated innate immune responses by carboxylation
Tomohiko Okazaki (The University of Tokyo)

Category-15: Mycofungal/ parasite infection
3-C-W26-7-O/P
Effect of Secreted Immunoglobulin Deficiency in Anti-Leishmania Immunity
Piyarat Srinontong (Gifu University)
3-C-W26-19-O/P
Strategy of Zygomycete fungi to evade anti-fungal innate immunity
Masashi Kanayama (Duke University)

Category-16: Bacterial infection
3-C-W27-5-O/P
Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
Kouyuki Hirayasu (Osaka University)
3-C-W27-6-O/P
Recognition of mycobacterial lipid by Dendritic cell immunoactivating receptor
Kenji Toyonaga (Kagoshima University)

Category-17: Endogeneous innate immunity and inflammation
3-B-W24-17-O/P
Involvement of RNAi accessory factors in MDA5/LGP2-mediated cellular responses by Cardiovirus infection
Akihiko Komuro (Niigata University)
3-B-W24-20-O/P
Immune regulation through TRIM-regulated precision autophagy and secretion.
Tomonori Kimura (Osaka University)

Category-18: Mucosal-Skin Immunity
1-A-W1-15-O/P
Commensal bacteria-derived metabolite induce colonic IgA producing cells
Junya Isobe (Keio University)
1-A-W2-8-O/P
Immunization with GM-CSF-induced RALDH2-expressing dendritic cells induce antigen-specific IgA and Th responses in intestine
Naoki Takemura (Chiba University, The University of Tokyo)

Category-19: Tolerance and Immune suppression
2-D-W18-6-O/P
Non-overlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
Baihao Zhang (Kyoto University, RIKEN-IMS)
2-D-W18-12-O/P
Hepatic IL-10 producing CD11b+ macrophage recruited in colitic mice prevent T-cell-dependent hepatitis via gut-liver axis
Nobuhito Taniki (Keio University)

Category-20: Organ-specific autoimmune diseases
3-F-W32-2-O/P
The anti-apoptotic effect of matrix metalloproteinase-2 suppresses streptozotocin-induced diabetes by activating the Akt signaling pathway
Kota Nishihama (Mie University)
3-F-W32-4-O/P
Regulation of neuroinflammation by a cellular metabolite in experimental autoimmune encephalomyelitis
Daisuke Kamimura (Hokkaido University)

Category-21: Inflammatory arthritis
2-C-W17-2-O/P
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Takaichi Okano (Kobe University)
2-C-W17-6-O/P
Histone lysine methylation and STAT3 differentially regulate constitutive nad IL-6-induced MMPs gene activation in rheumatoid arthritis synovial fibroblasts
Yasuto Araki (Saitama Medical University)

Category-22: Systemic autoimmune diseases
1-F-W11-5-O/P
IL-21 enhances the development of autoimmune myositis via the production of GM-CSF from gd T cells
Takahiro Kageyama (Chiba University)
1-F-W12-1-O/P
Cell-type-specific transcriptome analysis of peripheral blood mononuclear cells (PBMCs) revealed B cell contribution to systemic lupus erythematosus pathogenesis
Yusuke Takeshima (The University of Tokyo)

Category-23: Tumor immunity
2-A-W15-12-O/P
IL-33 promotes obesity-associated liver cancer development
Fumitaka Kamachi (Tokyo University of Science)
3-A-W22-5-O/P
A novel pathogenic role of interleukin-34 in cancer chemoresistance
Muhammad Baghdadi (Hokkaido University)

Category-24: Human Immunology (Immunointervention)
1-D-W7-11-O/P
Gene Modules Correlated with Disease Activity and Abatacept Treatment Identified with Weighted Gene Co-Expression Network Analysis of CD4+ T Cell Subsets of Rheumatoid Arthritis
Shuji Sumitomo (The University of Tokyo)
1-D-W8-2-O/P
Development of molecular targeted therapy for human acute GVHD in humanized mice
Genki Okumura (University of Tsukuba)

Category-25: Antigen presentation, Trafficking
3-E-W31-6-O/P
HLA-F and MHC open conformer cooperate in antigen presentation during the inflammatory response
Akiko Ishitani (Nara Medical University)
3-E-W31-8-O/P
Implications of Spns2-deficiency on S1P-driven lymphocytes egress, HEV-integrity and immunity.
Szandor Simmons (Osaka University)

2015年

Category-1: Hematopoiesis and Immune Environment
2-I-W32-7-O/P
Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection Ari Itoh-Nakadai (Tohoku University)
2-I-W32-10-O/P
Identification of cMoP and bona fide GMP in human umbilical cord blood
Shunsuke Kawamura (Tokyo Medical and Dental University)

Category-2: B cells
3-F-W42-2-O/P
Intrathymic licensing of immigrating peripheral B cells for T cell tolerance induction
Tomoyoshi Yamano (Ludwig-Maximilians-Universitat)
3-F-W42-3-O/P
Antigen-spe cific maturation of anti-nuclear antibodies in systemic lupus erythematosus
Shuhei Sakakibara (Osaka University)

Category-3: T cells
2-H-W30-1-O/P
A tumor suppressor Menin controls CD8 T cell senescence by regulating energy metabolism
Junpei Suzuki (Ehime University)
3-H-W46-3-O/P
Statistical analysis shows non-randomness of V/J gene selection in human TCR
Yotaro Katayama (The University of Tokyo)

Category-4: Helper T cells
1-H-W13-4-O/P
Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1
Yusuke Endo (Chiba University)
1-H-W14-11-O/P
Human CXCL13-producing CD4 T cells preferentially differentiate under IL-2-limitted environment
Hiroyuki Yoshitomi (Kyoto University)

Category-5: Regulatory T cells
3-G-W43-2-O/P
Establishment of regulatory T cell-specific super-enhancers
Yohko Kitagawa (Osaka University)
3-G-W43-6-O/P
Foxp3 changes its partners and genomic binding regions in regulatory T cells in response to IL-4 stimulation
Norihito Hayatsu (RIKEN-IMS)

Category-6: Innate lymphocytes
1-C-W4-7-O/P
Involvement of Natural Helper cells, a member of group 2 ILCs (ILC2) in the induction of obesity
Takaharu Sasaki (RIKEN-IMS)
1-C-W4-2-O/P
Identification of progenitor cells specific to ILC1s and ILC3s in adult intestine
Takashi Ebihara (Washington University)

Category-7: Dendritic cells and macrophages
2-C-W20-1-O/P
Transcription factor IRF8 governs the enhancer landscape dynamics in mononuclear phagocyte development
Daisuke Kurotaki (Yokohama City University)
3-C-W36-2-O/P
Unique role of Cbfb2 variant in Langerhans cell development
Mari Tenno (RIKEN-IMS)

Category-8: Antigen presentation
1-D-W5-2-O/P
p62/Sqstm1 plays a specific role for CD8+ T cell activation in antigen presenting cells following IFN-γ-induced disruption of the Toxoplasma gondii parasitophorous vacuoles
Youngae Lee (Osaka University)
1-D-W5-13-O/P
Discovery of lipopeptide Ag-presenting molecules: its molecular identity and X-ray crystallographic structure
Daisuke Morita (Kyoto University)

Category-9: Trafficking
2-I-W31-5-O/P
Spinster-homologue-2 (Spns2) controls S1P-driven lymphocyte egress from lymphoid organs
Szandor Simmons (Osaka University)

Category-10: Mast cells & granulocytes
1-C-W3-3-O/P
The hIstidine transporter SLC15A4 regulates allergic responses by tuning the endo/lysosomal condition of mast cells
Toshihiko Kobayashi (National Center for Global Health & Medicine)
1-C-W3-4-O/P
The novel role of LMIR7/CLM-3 in mast cell- and IgE-dependent anaphylaxis
Masamichi Isobe (Juntendo University)

Category-11: Allergy
3-I-W47-4-O/P
Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways
Shoko Akasaki (Hyogo College of Medicine)
3-I-W48-4-O/P
CXCL4 is a novel nickel binding protein and augments nickel allergy at elicitation phase
Toshinobu Kuroishi (Tohoku University)

Category-12: Cytokines and chemokines
1-I-W15-4-O/P
Inflammation amplifier regulatory molecule NSZ1 controls NFκB specific chromatin accessibility via alternative splicing of a DNA methyltransferase
Toru Atsumi (Hokkaido University)
1-I-W16-8-O/P
Involvement of a novel alpha9 integrin ligand, XCL1/Lymphotactin in autoimmune diseases
Naoki Matsumoto (Hokkaido University)

Category-13: Immunological memory
1-G-W11-3-O/P
Distinct germinal center selection at local sites shapes memory B cell response to viral escape
Yu Adachi (National Institute of Infectious Diseases)
1-G-W11-5-O/P
A role of IL-9 receptor on B cells in the T-dependent immune responses
Shogo Takatsuka (Tokyo University of Science)

Category-14: Virus infection
1-F-W9-2-O/P
The role of mTOR in TLR3 responses to Herpes Simplex Virus infection
Ryota Sato (The University of Tokyo)
1-F-W10-6-O/P
CD150 costimulation enhances SHIV-specific TFH cell responses in non-human primate models
Takuya Yamamoto (National Institutes of Biomedical Innovation, Health and Nutrition)

Category-15: Mycofungal/ parasite infection
1-E-W7-14-O/P
Batf2 regulates Th17 responses by suppression of IL-23 production during Trypanosoma cruzi infection
Shoko Kitada (Osaka University)
1-E-W7-18-O/P
Malaria-induced bone disorder triggered by chronic inflammation in the bone
Michelle Sue Jann Lee (Osaka University)

Category-16: Bacterial infection
3-G-W44-6-O/P
Analysis of a novel subset of IFN-γ-producing DN2a γδ T cells in the periphery of mice
Shinya Hatano (Kyushu University)
3-G-W44-4-O/P
CD300a on mast cells and dendritic cells control the pathogenesis of experimental sepsis
Gamage Sanath Udayanga Kankanam (University of Tsukuba)

Category-17: Endogeneous innate immunity and inflammation
1-G-W12-1-O/P
MD-1 negatively regulates B cell-related inflammation
Natsuko Tanimura (The University of Tokyo)
2-G-W27-3-O/P
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection
Ryo Narita (Kyoto University)

Category-18: Mucosal-Skin Immunity
3-E-W40-1-O/P
The role of the gut microbiota in the development of experimental autoimmune encephalomyelitis
Eiji Miyauchi (RIKEN-IMS)
1-E-W8-1-O/P
Lypd8 maintains gut homeostasis through separation of flagellated bacteria and colonic epithelia
Ryu Okumura (Osaka University)

Category-19: Tolerance and Immune suppression
2-C-W19-3-O/P
Establishment of thymus transplant model to analyze peripheral T cell tolerance against pemphigus autoantigen, desmoglein 3
Hisato Iriki (Keio University)
2-C-W19-4-O/P
The strength of inhibition by LAG-3 depends on properties of APCs
Takumi Maruhashi (Tokushima University)

Category-20: Organ-specific autoimmune diseases
2-F-W25-1-O/P
RANKL on T cells is essential for inflammation in the CNS during EAE
Matteo Maurizio Guerrini (The University of Tokyo)
2-F-W26-6-O/P
Activated increased number of T follicular helper subset 2 correlates with increased levels of IgG4, IL-4 and plasmablasts in IgG4-related disease
Mitsuhiro Akiyama (Keio University )

Category-21: Inflammatory arthritis
2-B-W17-1-O/P
Rheumatoid arthritis patients-derived gut microbiota induce Th17-mediated arthritis in SKG mice
Yuichi Maeda (Osaka University)
2-B-W17-2-O/P
TIARP regulates CXCL2/CXCR2 mediated neutrophil migration via the inhibition of IL-6
Asuka Inoue (University of Tsukuba)

Category-22: Systemic autoimmune diseases
1-B-W1-5-O/P
Regulatory roles of TGF-β3 in lupus pathogenesis
Toshihiko Komai (The University of Tokyo)
1-B-W2-1-O/P
Myeloperoxidase/HLA class II complexes are targets for autoantibodies in ANCA-associated vasculitis
Ryosuke Hiwa (Kyoto University)

Category-23: Tumor immunity
2-D-W21-8-O/P
Metformin administration stimulates glycolysis of effector memory CD8TIL in tumor microenvironment Shingo Eikawa (Okayama University)
3-D-W38-5-O/P
Tumor cell death accelerated migration of tumor infiltrating dendritic cells into draining lymph nodes
Taiki Moriya (Osaka Ohtani University)

Category-24: Human Immunology (Immunointervention)
2-B-W18-3-O/P
The ulcerative colitis-associated gene RNF186 regulates gut homeostasis
Kosuke Fujimoto (Osaka University)
3-B-W34-5-O/P
Development of a human hemato-lymphoid system in human cytokine knock-in Rag2-/-Il2rg-/- mice engrafted with peripheral blood mobilized CD34+ cells
Yasuyuki Saito (Kobe University / University Hospital Zurich)

2014年

Category-1: Hematopoiesisand Immune Environment
2-H-W32-5-0/P : YANAGIHARA Toyoshi (Kyushu University)
Identification of a novel molecule essential for Aire expression and self-tolerance

Category-2: B cells
2-G-W29-8-O/P : YAMAZAKI Nao (National Center for Global health and Medicine)
IgM+ plasma cells contribute to the sufficient production of IgG by secreting IL-10 and IL-13

Category-3: T cells
2-D-W23-6-O/P : KAMIMURA Daisuke (Hokkaido University)
Characterization of T-Red mutant mouse line having reduced naive T cells

Category-4: Helper T cells
3-E-W44-5-O/P : SANO Teruyuki (New York University)
Cytokine requirement for Th17 cell differentiation in response to Segmented filamentous bacteria colonization

Category-5: Regulatory T cells
3-D-W42-16-O/P : MURAKAMI Ryuichi (RIKEN)
Foxp3 and BATF cooperatively controls regulatory T cell homeostasis in non-lymphoid tissues

Category-6: Innate lymphocytes
1-B-W2-8-O/P : MIYAJIMA Michio (RIKEN)
Type III innate lymphoid cells enhance antibody production by splenic marginal zone B cells

Category-7: Dendritic cells and macrophages
2-C-W22-1-O/P : NIIZUMA Kouta (University of Tsukuba)
Identification and characterization of human CD300H, the eighth member of the CD300-family receptors

Category-8: Antigen presentation
2-E-W26-9-O/P : KISHIDA Kazuki (Osaka University)
Processing of cellular misfolded protein complexed with MHC class II molecules

Category-9: Trafficking
1-F-W9-13-O/P : HARADA Yosuke (Kyushu University)
The role of DOCK8 in migration and activation of effector CD4+ T cells during immune responses

Category-10: Mast cells & Granulocytes
2-J-W36-7-O/P : ANDO Tomoaki (RIKEN)
Mast cells and the Stat5 activation pathway are required for allergen-induced and spontaneous skin inflammation

Category-11: Allergy
1-J-W18-3-O/P : TSAI Shin han (Osaka University)
E-NPP3 (CD203c) negatively regulates ATP-dependent allergic responses by basophils and mast cells

Category-12: Cytokines and chemokines
3-G-W47-17-O/P : OGURA Hideki (Hokkaido University)
ZFZ (zinc finger motif containing protein Z) promotes the inflammation amplifier by regulating NF-κB DNA binding activity

Category-13: Immunological memory
1-G-W11-1-O/P : KONDO Taisuke (Keio University)
Generation of mouse CD4⁺ stem cell memory T cells by Wnt signaling and by Notch signaling

Category-14: Virus infection
2-I-W34-2-O/P : SUGIMOTO Naoshi (Kyoto University)
Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

Category-15: Mycofungal / parasite infection
3-I-W52-4-O/P : UENO Keigo (National Institute of Infectious Diseases)
Efficacy of dendritic cell-mediated immunization for the pulmonary infection with highly virulent fungus Cryptococcus gattii

Category-16: Bacterial infection
3-I-W51-9-O/P : TSUCHIYA Kohsuke (Kyoto University)
NLRP3 and ASC contribute to host defense against pneumococcal pneumonia in an inflammasome-independent manner

Category-17: Endogeneous innate immunity and inflammation
2-E-W25-6-O/P : IMAMURA Tomoko (Kyoto University)
N4bp1-mediated nascent RNA decay controls cytokine mRNA expression

Category-18: Mucosal-Skin Immunity
3-H-W49-5-O/P : GOTO Yoshiyuki (Columbia University)
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation

Category-19: Tolerance and Immune suppression
1-H-W13-3-O/P : LIN Youwei (NCNP)
Inverse vaccination for autoimmune diseases by sensitization of superior dominant peptide through efficient induction of functionally stable regulatory T cells possessing high antigen-specificity

Category-20: Organ-specific autoimmune diseases
1-F-W10-2-O/P : ASASHIMA Hiromitsu (University of Tsukuba)
The suppressive ability of altered peptide ligands to M3R reactive T cells in M3R induced autoimmune sialadenitis

Category-21: Rheumatoid arthritis
2-F-W28-1-O/P : KONDO Yuya (University of Tsukuba)
RORγt+Foxp3+ regulatory T cells regulates the development of autoimmune arthritis in mice

Category-22: Systemic autoimmune diseases
3-F-W45-7-O/P : MORITA Kaoru (The University of Tokyo)
The role of Egr2 and Egr3 in regulating immune homeostasis

Category-23: Tumor immunity
2-B-W19-8-O/P : MAEDA Takuya (Kyoto University)
Regeneration of EB virus LMP2 specific CTLs utilizing iPS technology

Category-24: Human Immunology (immunointervention)
3-C-W40-7-O/P : NAKACHI Shinichiro (The University of Tokyo)
A quantitative alteration of human CD4+CD25-LAG3+Tregs in patients with rheumatoid arthritis